Indication
Prevention of transplant rejection after solid organ transplantation
Treatment of cell rejection in patients who have received other immunosuppressive agents
Prevention of graft rejection after allogeneic bone marrow transplant and stem cell transplant
Prevention or treatment of graft versus host disease (GVHD)
Treatment of intermediate or posterior uveitis of non-infectious origin, threatening vision, in patients who have not responded to conventional therapy or who have experienced unacceptable side effects following such therapy
Treatment of Behçet’s uveitis with repeated inflammatory attacks involving the retina in patients without neurological manifestations
Treatment of corticosteroid-dependent and corticosteroid-resistant nephrotic syndrome, secondary to a primary glomerular pathology such as minimal lesion nephropathy, focal segmental glomerulosclerosis or extra-membranous glomerulonephritis
Treatment of severe and active forms of rheumatoid arthritis
Treatment of severe forms of psoriasis when conventional therapy has been shown to be inadequate or ineffective
Treatment of severe atopic dermatitis requiring systemic treatment
Use

Solid organ transplant
Start treatment with ciclosporin within 12 hours of surgery
Initial dose: at 15 mg / kg, to be administered in 2 divided doses
Continue to administer this daily dose for 1 to 2 weeks after the procedure, then gradually reduce the dose according to blood concentrations, until a recommended maintenance dose of approximately 2 to 6 is obtained. mg / kg, to be administered in 2 divided doses

Bone marrow transplant
Recommended daily dose: 12.5 to 15 mg / kg, to be administered in 2 divided doses
Treatment should start the day before the transplant

Endogenous uveitis
Initial dose: 5 mg / kg / day, in 2 divided doses
Refractory cases: the dose may be increased to 7 mg / kg / day for a limited time
During the remission phases: max. 5 mg / kg / day

Nephrotic syndrome
Adults: recommended daily dose of 5 mg / kg
Children: recommended daily dose of 6 mg / kg
Max. 5 mg / kg / day in adults and 6 mg / kg / day in children
Initial dose: max. 2.5 mg / kg / day

Rheumatoid arthritis
Recommended dose: 3 mg / kg / day in 2 divided doses for 6 weeks
Combination with a weekly low dose of methotrexate: starting dose of 2.5 mg / kg of ciclosporin per day
If the effect is insufficient, then the daily dose can be gradually increased, depending on the patient’s tolerance.
Max. 5 mg / kg

Psoriasis
Recommended initial dose: 2.5 mg / kg / day, in 2 divided doses.
If there is no improvement after 1 month of treatment, the daily dose may be gradually increased
Max. 5 mg / k

Atopic dermatitis
Recommended dose: 2.5 to 5 mg / kg / day, in 2 divided doses.
If the effect is insufficient after 2 weeks of treatment, the daily dose can be rapidly increased up to a maximum of 5 mg / kg

Administer the daily dose of ciclosporin in two separate doses, spread evenly over the day.
It is recommended that ciclosporin be administered on a regular schedule, depending on the time of day and meals
Swallow ciclosporin capsules whole